MDR-1 mutation - sensitivity to drugs in OES
Anyone ever heard of this? Tina |
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| I just took my new puppy Dahlia to our vets tonight and she gave me a listing of this and discussed this with me. You can get a cheek swab or some sort of test done and they will send it in so you can find out if your OES has this mutation or not. |
 I had no idea that Comfortis had Ivermectin in it! WOW! I may be late on knowing that too but, I wonder how they can sell in over the counter since Ivermectin at a vet you have to have a prescription... Now I need to see what I am missing too!  Thank you! |
| Oh, sorry, I think I confused you -- Comfortis does not have ivermectin in it, but it can interact wtih Ivermectin -- and I think this problem is true for all dogs, not just those with the gene mutation. But I know in my case, since the comfortis was given monthly, and so was the heartguard (ivermectin) I gave them at the same time -- and if you have a dog with the gene mutation, that could be asking for trouble. The FDA warning (you can google it and find it) says that the heartworm prevention dose of ivermectin is safe with comfortis - but it would make me a little uneasy about giving them together -- and if you are giving ivermectin at higher doses (i.e. for treating mange), then you should definitely not use comfortis. hope that clears things up! sorry about that! |
| Yes, MDR1 is a concern w/ OES, as part of the herding group of dogs. Our dogs have all been tested, and it's quite a simple test. We did a group (grown littermates) a few years ago. I know at least 6 of the 8 littermates were done. I swabbed the 3 in MN, and they got sent in w/ the 3 in WI. Ours are normal/normal, and I know 1 in the group was mutant/normal (mutant/mutant is what you don't want). It's a good test to have done. There have been several discussions on here about it, but this is certainly a valid one worth bringing up again  |
Guest wrote: Oh, sorry, I think I confused you -- Comfortis does not have ivermectin in it, but it can interact wtih Ivermectin -- and I think this problem is true for all dogs, not just those with the gene mutation. But I know in my case, since the comfortis was given monthly, and so was the heartguard (ivermectin) I gave them at the same time -- and if you have a dog with the gene mutation, that could be asking for trouble. The FDA warning (you can google it and find it) says that the heartworm prevention dose of ivermectin is safe with comfortis - but it would make me a little uneasy about giving them together -- and if you are giving ivermectin at higher doses (i.e. for treating mange), then you should definitely not use comfortis. hope that clears things up! sorry about that!  Good gracious, I do confuse easily! I should have read slower!  Still very good to know! I do not use Comfortis but, that is REALLY important info to get out there! Thank you! |
| There is a very good & imformative article in the March 2011 OET on drug sensitivity for those of you who get the OET. Having a boy who has a sensitivity to Flagyl, this was very intersting to me. |
| BTW, I did have Dahlia tested for this and it was fine. She doesn't have the mutant gene. I am glad I did it since she will be spayed at some point and I have a little piece of mind that she won't have a reaction to the anesthesia. |
NJ_Sheepie wrote: BTW, I did have Dahlia tested for this and it was fine. She doesn't have the mutant gene. I am glad I did it since she will be spayed at some point and I have a little piece of mind that she won't have a reaction to the anesthesia. Not intended to scare you in any way - a reaction is very unlikely - but one of my girls reacted very badly to ketamine administered when I had her OFA x-rays taken. My vet suggested I get her tested for the MDR1 mutation "just in case" ( I don't think ketamine is one of the drugs listed among those MDR1 affected dogs have sensitivities too, but...?) She came back normal/normal. So just because they don't carry the mutation, and I think it's great that you checked, there can be other drug sensitivities for reasons as yet unknown. Unlikely, mind you. Just mentioning it as an outside possibility. Kristine |
| My vet is switching from carrying regular Comfortis to Trifexis, which is a combination of Comfortis (flea control) and Interceptor (heartworm and intestinal parasite protection.) I don't plan on giving my dogs the combo- (we don't really have a heartworm problem here) but I would be concerned there would still be a reaction. Is Interceptor that same as ivermectin? |
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