Liver Enzme test
We need to take him back next week and run his ALT again he has been home for 2 weeks taken pills for the liver. His liver biopsy came back showing positive of copper staining/storage. They are doing one more test on this as well. Vet keeps saying could be a mushroom but I am leaning more on long term use and possible overdose of PB for seizures. I have been trying to read up on this and get answers but no such luck. I do know the vet stated they won’t put him back on PB. Because he has a weak liver now. He is now back home seems to be doing well but he also has been barking at a lot more noises and seems to be more protective. If anyone can give us answers it would be great we really don’t want our little boy to go through this again. Thanks |
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| Wow, that's a lot to deal with...I'm so sorry and I hope your boy will be OK. As much as I know we'd all love to help, this is probably beyond this board. Nonetheless, and keep in mind I'm not a vet, a couple of things come to mind: Long term PB use would be my first suspect as the cause of the liver issues as well. Have they talked about other drugs to control his seizures? Some dogs do well on potassium bromide, some times alone, some times in conjunction with a lower level of PB if he can tolerate it. The copper they found upon biopsying his liver - did they give you a reason? There is a copper storage disease best known in Bedlingtons, but I know an OES who was diagnosed with this as well. It looks like it may also occur in labs ( http://vet.sagepub.com/content/46/3/484.full ) If so, some tweaking of his diet may be in order as well. Doesn't mean it's relevant for your boy -obviously something you need to discuss with your vet(s). Wishing you and your boy all the best. Kristine |
| I'm sorry... I seldom ever read this section so I missed your post. I don't have any experience though we came close to having a biopsy done on our Schipperke-mix to determine the cause of high ALT (around 1,200 at it's highest, copper storage was briefly discussed however all other liver numbers were normal). The following articles on Copper Storage Disease may be helpful- http://www.peteducation.com/article.cfm ... 03&aid=406 http://www.vin.com/proceedings/Proceedi ... &O=Generic More scientific articles specifically mention that Labrador Retrievers can be afflicted- http://vet.sagepub.com/content/46/3/484.full http://wvc.omnibooksonline.com/data/pap ... 0_V137.pdf http://veterinarymedicine.dvm360.com/ve ... =&pageID=3 There is a brief statement in the book, "Handbook on the toxicology of metals" By Gunnar Nordberg about Phenobarbital and copper metabolism. See page 542. http://books.google.com/books?id=nKulgz ... &q&f=false I have no idea how or even if this applies so it's important to discuss it with your vet. Make no changes without your vet's guidance. Hoping you and your vet can figure this out and that your boy will be ok. |
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