Drug Interactions
I've read that OES can have alot of reactions to Meds. Are there any pain meds or anything else surgery related that I need to be careful with. Thanks Lisa |
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| Are you on about the MDR 1 gene in herding dogs ?
If so here is a few drugs you should watch:- Known or potential problem drugs Acepromazine Butorphanol Chinidin Cyclosporin Dexamethasone Digoxin Domperidone Doxorubicin Ebastine Erythromycin Etoposide Grepafloxacin Hydrocortisone Ivermectin Loperamide Mitoxantrone Morphine Moxidectin Ondansetron Paclitaxe Quinidine Rifampicin Selamectin Sparfloxacin Tacrolimus Vinblastine Vincristine |
| I understand your concern... I have two that appear to have had an allergic reaction to Metronidazol of all things. I don't know that you can predict an allergy or reaction to something except maybe if a relative had an problem.
Dogs with the MDR1 gene mutation do not process drugs properly out of the brain. You can do the mouth swabs yourself and send them off for testing (currently $70) http://www.vetmed.wsu.edu/depts-VCPL/index.aspx All of mine have come back MDR1 normal/normal but the website indicates 5% of the OESs tested had the mutated gene. If you're concerned, it's just something you might want to talk over with your vet. Hugs to your baby... I hope he'll be feeling better soon. |
| I have a dog that had a reaction to Flagyl (Metrodiazonal is the generic name) almost 8 years ago. It was more of a sensitivity than an allergy. He couldn't handle the normal dosage. I ALWAYS stress to people to make sure & weigh their dog ....don't guess. They can lose several pounds quickly when vomitting or with diarreha. Needless to say, I have never used it again on him or any of my dogs & when he sired a litter I made sure to write the information down in the puppy folders. Doesn't mean those puppies would have a problem with the drug but at least the owners & the vet were aware of the possibility. |
Quote: Needless to say, I have never used it again on him or any of my dogs & when he sired a litter I made sure to write the information down in the puppy folders. Doesn't mean those puppies would have a problem with the drug but at least the owners & the vet were aware of the possibility.
That's excellent! I think it's the only way someone could know ahead of time that there's even a slight possibility of a reaction. One on-call vet was skeptical that it would cause a reaction but I've had two that had facial swelling after the first dose. http://oesusa.com/Metronidazole-Kaytee.jpg I requested their charts be marked so they aren't given the medication again... but I still try to pay attention to what's prescribed. |
6Girls wrote: Quote: Needless to say, I have never used it again on him or any of my dogs & when he sired a litter I made sure to write the information down in the puppy folders. Doesn't mean those puppies would have a problem with the drug but at least the owners & the vet were aware of the possibility. That's excellent! I think it's the only way someone could know ahead of time that there's even a slight possibility of a reaction. One on-call vet was skeptical that it would cause a reaction but I've had two that had facial swelling after the first dose. http://oesusa.com/Metronidazole-Kaytee.jpg I requested their charts be marked so they aren't given the medication again... but I still try to pay attention to what's prescribed. It must cause a lot of different reactions. My boy ended up at Ohio State University! Basically what his reaction was, was vertigo. Hard to tell tho' at the onset when he acted like he couldn't stand, had a high temp & gave the impression of seizing. The clue that solved the problem was his eyes were going in opposite directions in circles  . The specialists down there came out & asked me what meds he'd been on in the last 3 months. I pulled out a baggie with everything he's been on in the last year. As soon as they saw that med. they knew it was the culprit. Said not to be too hard on my vet as he could practice for 40 years & never see this happen. But now he'd never forget it either. They gave him valium & flushed his sytem out with water via IV's & he ended up just fine. But we sure thought he was a gonner for awhile there. I even note it on the sheet of instructions I send to the kennel whenever we have to kennel them for vacations etc. That way incase of an emergency they know NOT to ever give any of my dogs that medicine. He was 4 years old when this happened & his 12th birthday is coming up here pretty soon. Since we weren't sure where this sensitivity came from we decided that anything we bred that went back to him or his father would have the notation in the puppy folders. |
| Marilyn, another person told me her bitch, a cross of two very different lines, and unrelated to your (and my) lines, as much as this is possible in our breed, had a somewhat similar reaction to flagyl a few years back. So that sensitivity may just be floating around in the breed and we should all be a bit careful. She ran the MDR1 test and it came back normal/normal so that was not the issue.
Same with me when Mad had a bad reaction to ketamine and her temp spiked suddenly and dangerously and my vet had to bring her back out in a big hurry. Very scary. We even ran a bile acid test to rule out liver dysfunction, but that was normal too. So, yes, the MDR1 mutation can explain some sensitivites, but not all. Makes me wonder if there are other mutations out there no one has had reason to look for. In Mad's case I spoke to the breeder of her sire and she said she had lost a couple of bitches over the decades during OFA hip x-rays, which is when Mad had her reaction to the ketamine. She couldn't remember a specific drug tie-in, but it makes you wonder. I did what you did and simply noted that in the puppies' accompanying paperwork in big cautionary letters just in case. 
Kristine |
| I lost my Elizabeth (Ch. Kenbears Echo of Thunder) to Metronitazole in 2009. The vet didn't recognize the reaction since it is usually so "safe" and gave her a second dose at 10pm. She was gone by 8:30am the next morning. I had a necropsey at Michigan State University and her liver was destroyed - the only toxin in her body was the drug. I had her daugher and grandson tested for the MDR1 gene and they both came back normal/normal, so there may just be a sensitivity to the drug in some Sheepies. |
Hollyjoychase wrote: I lost my Elizabeth (Ch. Kenbears Echo of Thunder) to Metronitazole in 2009. The vet didn't recognize the reaction since it is usually so "safe" and gave her a second dose at 10pm. She was gone by 8:30am the next morning. I had a necropsey at Michigan State University and her liver was destroyed - the only toxin in her body was the drug. I had her daugher and grandson tested for the MDR1 gene and they both came back normal/normal, so there may just be a sensitivity to the drug in some Sheepies. Hi Holly! And welcome! And yes, that is what Ohio State told me about Isaac. A sensitivity to the drug. Needless to say I watch all my dogs like a hawk since this happened 8 years ago. What they also told me was the reaction is rare. So rare that they only see 4 cases a year & they get all the weirdo cases being a veterinary teaching hospital. A vet could go thru all the years of his practice & never have something like this happen. But once they saw it happen, they'd never forget it. I am lucky in that my vet is such a down-to-earth person. He was humble enough to tell me he had tried everything he knew of & couldn't figure out the problem...it was time to go somewhere else. And he sent me to Ohio State that very minute. |
| I'm so sorry you lost Elizabeth... such a lovely girl. Both of mine that had allergic reactions to Metronidazole also tested Normal/Normal for the MDR1 gene so it's some other type of sensitivity. http://oesusa.com/Metronidazole.jpg It makes it difficult because we don't know ahead of time whether this medication will help or harm our dogs. |
| Wow, we've never had a reaction to any of the drugs mentioned. And I always thought my dogs were super sensitive to everything. The only thing we had a reaction to was the shot for Lepto - which is controversial anyway. After my older dog had a reaction, when we got his half sister a few years later, my Vet treated her the same as if she would get the same reaction since the blood lines were the same. Never had a problem again. My dogs, both, have been on Metronidozle and also never a probem... I would suggest, if you fear a reaction, give half the dose and watch for reaction. Good Luck...Hope nothing happens and Frankie feels better soon. |
Hollyjoychase wrote: I lost my Elizabeth (Ch. Kenbears Echo of Thunder) to Metronitazole in 2009. The vet didn't recognize the reaction since it is usually so "safe" and gave her a second dose at 10pm. She was gone by 8:30am the next morning. I had a necropsey at Michigan State University and her liver was destroyed - the only toxin in her body was the drug. I had her daugher and grandson tested for the MDR1 gene and they both came back normal/normal, so there may just be a sensitivity to the drug in some Sheepies. I have an Elizabeth grandson, too and our vet knows without me even reminding her that Owen never gets Metronitazole. We never had the test but it's easier not to take the chance. |
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