Advantix reaction

Every month for the last 3.5 years, I applied Advantix to Saffy (4 yrs old) without any reaction. We live in FL and she goes to the dog park daily so she is exposed to fleas. Last month, she reacted when I applied it. She ran around, up and down the stairs. I am horrified to realize that I didn't connect her reaction to the application. This morning, she reacted the same, but this time I saw that she was in discomfort and I immediately washed it off. Anybody else have this experience or know of any recall or problem with Advantix? I plan to call their hotline when they open up this morning.
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