FIBROSARCOMAS at Vaccine Injection Sites in Dogs
The following quote is from the full study text: "In both dogs and cats, the development of necrotizing panniculitis at sites of rabies vaccine administration was first observed by Hendrick & Dunagan (1992)." Kris L. Christine ledgespring@lincoln.midcoast.com Founder, Co-Trustee THE RABIES CHALLENGE FUND Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291(6) Vascellari M.[1]; Melchiotti E.[1]; Bozza M.A.[1]; Mutinelli F.[2] [1] Address of authors: Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'Università 10, 35020 Legnaro (PD), Italy; [2] Corresponding author:, Tel: +39 049 8084261, Fax: +39 049 8084258, Email: fmutinelli@izsvenezie.it Abstract: Summary Fifteen fibrosarcomas, surgically excised from presumed sites of injection in dogs, and 10 canine fibrosarcomas excised from sites not used for injection were histologically and immunohistochemically compared with 20 feline post-vaccinal fibrosarcomas. Canine fibrosarcomas from presumed injection sites were of grade I (3), of grade II (4) and grade III (8). Two fibrosarcomas from non-injection sites were of grade I, four of grade II and four of grade III. Feline samples were classified as grade I (2), grade II (4) and grade III (14). All fibrosarcomas from presumed injection sites of both species showed lymphocytic inflammatory infiltration located at the tumour periphery, while two canine fibrosarcomas from non-injection sites showed perivascular inflammatory infiltration within the neoplasm. All samples were immunohistochemically examined for vimentin, smooth muscle actin, muscle specific actin and desmin expression. All tumours were positive for vimentin. Ten canine fibrosarcomas from presumed injection sites and all feline samples contained cells consistent with a myofibroblastic immunophenotype. Aluminium deposits were detected in eight canine fibrosarcomas from presumed injection sites and 11 feline post-vaccinal fibrosarcomas by the aurintricarboxylic acid method. The present study identifies distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection sarcomas not only in cats, but also in dogs. Document Type: Research article ISSN: 0931-184X DOI (article): 10.1046/j.1439-0442.2003.00544.x SICI (online): 0931-184X(20030801)50:6L.286;1- Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz http://www.cedarbayvet.com/duration_of_immunity.htm What Everyone Needs to Know about Canine Vaccines, Dr. Ronald Schultz http://www.puliclub.org/CHF/AKC2007Conf ... ccines.htm World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm Scroll down to Vaccine Guidelines 2007 (PDF) The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at http://www.leerburg.com/special_report.htm . The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at http://www.aahanet.org/PublicDocumen...s06Revised.pdf . Veterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at http://www.newvaccinationprotocols.com/ |
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| Rabies, Leptospira, Lyme, are killed, adjuvanted vaccines. Adjuvants are vaccine components (such as aluminum hydroxide, aluminum phosphate) used to enhance the immunological response.
"The World Health Organization (WHO) in 1999 classified veterinary vaccine adjuvants as Class III/IV carcinogens with Class IV being the highest risk," IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 74, World Health Organization, International Agency for Research on Cancer, Feb. 23-Mar. 2, 1999, p. 24, 305, 310.) According to the 2003 American Animal Hospital Association's Canine Vaccine Guidelines http://www.leerburg.com/special_report.htm (Page 16), "...killed vaccines are much more likely to cause hypersensitivity reactions (e.g., immune-mediated disease)." Could this be due to the combination of mercury (thimersol) and aluminum additives in the same vaccine? Mercury (Thimersol) is commonly found as a preservative in killed, adjuvanted veterinary vaccines. The combination of the mercury (thimersol) and adjuvant components (aluminum hydroxide, aluminum phosphate) in the same vaccine are of considerable concern because of the reactive properties of aluminum, especially when in contact with mercury (thimsersol). Please see the information below, as well as a Congressional petition to remove aluminum additives in human vaccines. Remember, mercury (thimersol) is still used in veterinary vaccines along with aluminium. ___________________________________________________________________________________________________________________ Mercury and aluminium http://en.wikipedia.org/wiki/Mercuric Aluminum amalgam http://en.wikipedia.org/wiki/Mercury-aluminum_amalgam "Due to the reactivity of aluminium amalgam, restrictions are placed on the use and handling of mercury in proximity with aluminium. In particular, mercury is not allowed aboard aircraft under most circumstances because of the risk of it forming amalgam with exposed aluminium parts in the aircraft. In the Second World War, mercury was used to sabotage aircraft." Chemical Reactivity of Aluminum: http://www.sciencebyjones.com/chemical_reactivity.htm Petition to Congress "Removal of Aluminum Additive in Vaccines Resolution and Petition" www.petitiononline.com/NoMadVac/petition.html "The combination of mercury plus aluminum is far worse than the sum of the two toxicities added together. The synergistic toxicity could be increased to unknown levels." _____________________________________________________________ More information specifically on the rabies vaccine can be found at the following links if you are interested to learn more: Animal Wellness Magazine Article Vol. 8 Issue 6, How Often Does he REALLY Need A Rabies Shot Animal Wellness Magazine - devoted to natural health in animals The Rabies Challenge Animal Wise Radio Interview Listen to Animal Wise (scroll down to The Rabies Challenge 12/9/07) The Vaccine Challenge Animal Talk Naturally Online Radio Show » The Vaccine Challenge - Show #91 US Declared Canine-Rabies Free -- CDC Announces at Inaugural World Rabies Day Symposium CDC Press Release - September 7, 2007 Rabies Prevention -- United States, 1991 Recommendations of the Immunization Practices Advisory Committee (ACIP), Center for Disease Control's Morbidity and Mortality Weekly March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/mmwr/preview/mmwrhtml/00041987.htm "A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. " |
| In an August 1, 2008 article in DVM360 entitled Vaccination: An Overview,Dr. Melissa Kennedy states that of the two types of vaccinal adverse reactions: The second is a delayed response, requiring days of longer to develop. The vaccine, seen as foreign, elicits a significant inflammatory response and is especially true for adjuvanted vaccines. This response can manifest as a granuloma, or more seriously, a fibrosarcoma . Further, she reports that The likelihood of adverse reactions in dogs has been found to correlate with the size of the dog and the number of inoculations given, with higher risk associated with small size and multiple inoculations. http://veterinarycalendar.dvm360.com/av ... ?id=568351
____________________________________________________________________________________________________________________ Duration of Immunity: The Rabies Vaccine Challenge - Show #185 Animal Talk Radio Show 7/30/08 http://www.blogtalkradio.com/animaltalk ... e-Show-186 Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz http://www.cedarbayvet.com/duration_of_immunity.htm What Everyone Needs to Know about Canine Vaccines, Dr. Ronald Schultz http://www.puliclub.org/CHF/AKC2007Conf ... ccines.htm Vaccination: An Overview Dr. Melissa Kennedy, DVM360 http://veterinarycalendar.dvm360.com/av ... ?id=568351 World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm Scroll down to Vaccine Guidelines 2007 (PDF) The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at http://www.leerburg.com/special_report.htm . The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at http://www.aahanet.org/PublicDocumen...s06Revised.pdf . Veterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at http://www.newvaccinationprotocols.com/ October 1, 2002 DVM Newsletter article entitled, AVMA, AAHA to Release Vaccine Positions, http://www.dvmnewsmagazine.com/dvm/arti ... p?id=35171 July 1, 2003 DVM Newsletter article entitled, What Do We Tell Our Clients?, Developing thorough plan to educate staff on changing vaccine protocols essential for maintaining solid relationships with clients and ensuring quality care http://www.dvmnewsmagazine.com/dvm/arti ... p?id=61696 July 1, 2003, DVM Newsletter article, Developing Common Sense Strategies for Fiscal Responsibility: Using an interactive template to plan service protocol changes http://www.dvmnewsmagazine.com/dvm/article/articleDetail.jsp?id=61694 Animal Wellness Magazine Article Vol. 8 Issue 6, How Often Does he REALLY Need A Rabies Shot Animal Wellness Magazine - devoted to natural health in animals The Rabies Challenge Animal Wise Radio Interview Listen to Animal Wise (scroll down to The Rabies Challenge 12/9/07) The Vaccine Challenge Animal Talk Naturally Online Radio Show » The Vaccine Challenge - Show #91 Rabies Shot Killed my Poodle May 28, 2008 Channel 5 News WCVB http://www.thebostonchannel.com:80/news ... os&taf=bos US Declared Canine-Rabies Free -- CDC Announces at Inaugural World Rabies Day Symposium CDC Press Release - September 7, 2007 Rabies Prevention -- United States, 1991 Recommendations of the Immunization Practices Advisory Committee (ACIP), Center for Disease Control's Morbidity and Mortality Weekly March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/mmwr/preview/mmwrhtml/00041987.htm "A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. " |
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