Heartgard problems?
BTW - he's much better today. 
Ann |
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| I know a lot of dogs herding dogs (in particular collies) have an ivermectin sensitivity. My guys don't have any problems with it so we do use Heartgard but I know many people have been successful with Revolution. It's the kind that goes on the back of the neck. |
Sorry... had to change my post... 
What you've mentioned is an adverse reaction to HeartGard... I just opened a new box to look for the adverse reactions and there's NO product insert. What the heck is with that? You'd think it would be mandatory that a medicine have product information enclosed instead of having to visit their website 
http://heartgard.us.merial.com/download ... mation.pdf Quote: ADVERSE REACTIONS: The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea,mydriasis, ataxia, staggering, convulsions and hypersalivation. You might try Interceptor... my vet mentioned something about it not taking care of a certain type of... ?? worm eggs maybe?? I can't remember so just ask your vet so you get all the details. Quote: I know a lot of dogs herding dogs (in particular collies) have an ivermectin sensitivity. You can take an oral swab from your dog and send it off to Washington State University to be tested for the MDR-1 mutation. It will tell you if your dog carries a gene mutation that makes the very sensitive to certain drugs which causes toxicity in these affected dogs. I did the entire pack a few weeks back and all of them are normal. I always felt uneasy giving HeartGard not knowing for sure if they had issues so when I came across the testing info, I order them. I originally found it on the VetInfo4Dogs.com website but here's the direct link. http://www.vetmed.wsu.edu/depts-VCPL/test.aspx You get a report back that looks like this... Quote: MDR1 TEST RESULTS FOR:
Dog Name: Darby Dog Breed: Old English Sheepdpog Test Result: Normal/Normal Explanation of test results: Normal/Normal- These dogs do not carry the mutation, and will not pass on the mutation to their offspring. These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs. Mutant/Mutant- These dogs carry the mutation and can not pass on a normal gene to their offspring. These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram). Mutant/Normal- These dogs carry the mutation and may pass on the mutant gene to their offspring. These dogs may experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram). A current list of problem drugs for dogs with the MDR1 mutation may be found at this web address: http://www.mdr1test.com Note: They indicate the levels in commercial heartworm meds is supposed to be safe though... http://www.vetmed.wsu.edu/depts-VCPL/FAQ.aspx |
| Personally I'd be looking at using another brand for heartworm if he does get diarrhea and vomitting after he has the monthly heartworm tablet.
Definately some sort of reaction there to the brand you are presently using. Talk to your vet about trying another brand all together and see if there is any change after you administer it, if nothing then you know then there is a problem with using heartguard and one then to avoid using in the future with him.  |
| Consider switching to Interceptor. My vet's an OES breeder and that's all she'll give OES now.
I haven't noticed any difference since Heartguard never seemed to bother my guys in the first place, but, hey, she's the one who went to vet school so I don't argue with her
Kristine |
| I believe heartgard has something in it that is not good for sheepies or herding dog in general. My vet gave me papers to read up on it. She mentioned they use heartgard for other breeds but would not prescribe any for Obe. Instead she gave him/me a supply of Interceptor. I may have posted the information or at least the web site where it could be found here in the forum. I will try and find the paperwork and repost. |
| It's the MDR1 gene mutation.
Multi-Drug Resistance gene (MDR1) The more Old English Sheepdogs that are eventually tested, the better idea we'll all have about how prevalent the problem is within the breed. If you can afford the testing, it's part of a research program and sample collection is simple. http://www.vetmed.wsu.edu/depts-VCPL/instructions.aspx According to the VetInfo4Dogs.com website, 90% of the Old English Sheepdogs tested at the time the info was posted were normal. 10% tested sensitive or super sensitive. ...The problem is due to a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay--or even death.... "Drugs that have been documented or strongly suspected to cause problems in dogs with the MDR1 mutation" include Ivermectin*, Immodium (the anti-diarrhea drug), certain pre-anesthesia meds like Acepromazine and also some chemotherapy drugs. http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Quote: * Ivermectin (antiparasitic agent)-While the dose of ivermectin used to prevent heartworm infection is SAFE in dogs with the mutation (6 micrograms per kilogram), higher doses, such as those used for treating mange (300-600 micrograms per kilogram) will cause neurological toxicity in dogs that are homozygous for the MDR1 mutation (mutant/mutant) and can cause toxicity in dogs that are heterozygous for the mutation (mutant/normal).
If my dog had the mutation, I'd avoid ivermectin all together. |
| You can try interceptor instead but it still had the ivermectin in it.... You may also want to try the new Hartgard Plus.. It is a new flea medication that takes care of fleas, tick and heartworms through a topical application ( comes in tubes like advantage or frontline do.) |
Quote: You can try interceptor instead but it still had the ivermectin in it
The active ingredient in Interceptor is milbemycin oxime. I don't believe it contains ivermectin??? http://www.interceptor.novartis.us/dog/en/label.shtml There are STILL adverse reactions that can occur even with Interceptor though... |
| When I had rescued that little beagle and found out she had Mange the vet started to treat her with ivermectin .
Well a few days later I seen Junior starting to scratch and flipped  so I wanted to get my boys treated to make sure they did not get the mange.
When I went to the vet I was told " If white feet do not treat " Ok so what the heck does that mean ???? 
The vet said herding dogs have a extra Gene Mutation and Ivermection in high doses (like they give for mange)can be deadly to OES. 
The way the vets remember is by the saying "if white feet do not treat" from what the vet said most herding dogs have white feet. ( I did not know that ). Anyway, Harley gets sick to his stomach ever time I give him the Heartguard,Junior does not. 
So I just don't chance it. I use the Revolution and I love it ! It is a little more money since it goes by weight and my boys are COWS!!!!! 
But it treats everything and they have not had any problems. Antoinette |
| We use interceptor with success instead of heartguard. |
| I will never use Heartguard again.... I gave it to Brooklyn (my Bichon Frise) when she was about a year old, and she got so sick I thought she was going to die. It was horrible. So we switched to Interceptor and she never had any adverse reactions or worrisome side effects. So Interceptor is all I use with my dogs... Stella and Sampson also react very well to Interceptor. |
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