Ivermectin - Generic for Heartgard
Link to petdrugs.com |
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| There have been some bad reactions to Ivermectin with Herding breeds, mostly Shelties & Collie-types, so you may want to stay away from it. I have all of my pets on Revolution which protects against heartworm, fleas and certain kinds of mites. It's expensive but you are getting both flea protection & heartworm preventative in one. Only downfall is that it is not a tick preventative. |
| My vet says with invermectin....."white feet don't treat".....we use revolution as well....it works for fleas,ticks and heartworm...all in one |
| It sounds like she's already been using Heartgard but just wants to know if the generic is the same. I've never tried the generic either but wondered the same. Let me know if you do try it! |
| Yes, I had been using Heartgard, and have 3 months of advantage, so don't want to switch to Revolution quite yet. Thanks for your advise, and I guess I will stick with heartgard..... |
| The breeder had my puppy on Ivermection before we picked him up, she uses it on all of her dogs. She said it works just fine and is much cheaper. When I took Oliver's vaccination record to my vet, I asked him about it, and he said he didn't know anything wrong with using it, but just recommend using Heartguard. |
| Okay, sorry another post. Let me answer from a technical side.
I work in the medicated feed additive business (antibiotics, anti-coccs., etc.), mainly cattle, swine, poultry... but, what I do know is that before generic drugs are approved, they have to be shown to be equal to the pioneer. CVM (Center for Vet. Med) reveiws studies that are preformed by the generic to that of the pioneer to ensure they are equal. That means, the active drug must be the same chemical compound as the pioneer, as well as the drug carrier (other ingredients), stability dates, and manufacturing processes. So, from a technical side, I would say it would be fine to use Ivermection instead of Heartguard. But, if it were me, I would consult my vet, or at least do some research on any adverse effect studies. |
Shelly wrote: Does anyone use this brand instead of Heartgard? I need to order some more heartgard and this seems to run alot cheaper than the brand name, but wanted to know if anyone has used it......Thanks People keep saying ivermectin has adverse affects. Its the same active ingredient in Heartguard. Generic heartguard has same active ingredient, just different fillers like any other generic food or drug |
jcc9797 wrote: The breeder had my puppy on Ivermection before we picked him up, she uses it on all of her dogs. She said it works just fine and is much cheaper. When I took Oliver's vaccination record to my vet, I asked him about it, and he said he didn't know anything wrong with using it, but just recommend using Heartguard. Ivermectin is active ingredient in heartguard too. fillers in generic are just different. |
 If what you call "Ivermectin" is the same as what we call "Ivomec" - I think so - it shall NOT be used on Old English Sheepdogs, neither on collies. The dog might go in coma and never wake up again. I found this at Wikipedia: "Ivermectin can be given either by mouth or injection. It does not readily cross the blood-brain barrier of mammals,[citation needed] although crossing may still become significant if ivermectin is given at high doses (in which case, brain levels peak 2–5 hours after administration). In contrast to mammals Ivermectin can cross the blood-brain barrier in tortoises, with often fatal consequences". OES and Collies have another blood-brain barrier than other dogs and mammals. Like the guest say it is Ivermec in other medisin too, you have to make sure that it is in another chemical composition ( bigger molecules that cannot cross through the blood-brain barrier). Ask the vet. I have used Interceptor tablets and Stronghold on my oeses. If I wanted to use Ivomec tha vet asked me to write down that I took the risk that they may not wake up from coma - the fatal consequence that could happend if you use Ivomec.  |
| There is a DNA test (in the US anyway) for the drug sensitivity in ivomec/ivermectin now. If your dog is normal/normal, they are at no higher risk than any other dog. MDR1 testing is done with a mouth swab to obtain the sample, and is relatively inexpensive - I think it's about $70 now. Here's the site: http://www.vetmed.wsu.edu/depts-VCPL/test.aspx It's easy and something that should be done. Normal /normal is totally free, mutant/normal is at some risk, mutant/mutant "has" it and should not be treated with ivermectin and several other drugs. Please read the U of Washington's info on the website - very helpful! Chewie and sibs have all been tested, I do use Ivomec/ivermectin as HW preventative. (He is normal/normal) |
| We've tested all of our dogs too and they're all normal/normal. It does mention the following about Ivermectin on the Washington State University website... College of Veterinary Medicine Veterinary Clinical Pharmacology Lab http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Quote: Ivermectin (antiparasitic agent). While the dose of ivermectin used to prevent heartworm infection is SAFE in dogs with the mutation (6 micrograms per kilogram), higher doses, such as those used for treating mange (300-600 micrograms per kilogram) will cause neurological toxicity in dogs that are homozygous for the MDR1 mutation (mutant/mutant) and can cause toxicity in dogs that are heterozygous for the mutation (mutant/normal). |
got sheep wrote: There is a DNA test (in the US anyway) for the drug sensitivity in ivomec/ivermectin now. If your dog is normal/normal, they are at no higher risk than any other dog. MDR1 testing is done with a mouth swab to obtain the sample, and is relatively inexpensive - I think it's about $70 now. Here's the site: http://www.vetmed.wsu.edu/depts-VCPL/test.aspx It's easy and something that should be done. Normal /normal is totally free, mutant/normal is at some risk, mutant/mutant "has" it and should not be treated with ivermectin and several other drugs. Please read the U of Washington's info on the website - very helpful! Chewie and sibs have all been tested, I do use Ivomec/ivermectin as HW preventative. (He is normal/normal)  Great! - Let's hope that we can test it in Europe too: Ivomec is very effective. |
6Girls wrote: We've tested all of our dogs too and they're all normal/normal. It does mention the following about Ivermectin on the Washington State University website... College of Veterinary Medicine Veterinary Clinical Pharmacology Lab http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Quote: Ivermectin (antiparasitic agent). While the dose of ivermectin used to prevent heartworm infection is SAFE in dogs with the mutation (6 micrograms per kilogram), higher doses, such as those used for treating mange (300-600 micrograms per kilogram) will cause neurological toxicity in dogs that are homozygous for the MDR1 mutation (mutant/mutant) and can cause toxicity in dogs that are heterozygous for the mutation (mutant/normal).  Nice to know.......Don't know if I had dared to use it if my dog had MDR1/ the mutant gene.  |
| Grete - you'll have to let us know if you can test for it over there. I hope you can! |
| I just stay safe and dont use "heartguard, or anything containing "Invermectin, I use for heart worm "Interceptor" which contains no "Invermectin" and also treats "Intenstinal worms" as well on a monthly basis. OES having "Collies" in there background after learning about reactions in those breeds to anything containing "Invermectin" I changed to "Interceptor" just in case. When heartworm hit Melbourne only drug available back then was products containing "Invermectin" and non of my OES had any adverse reactions but over time some have here in Australia and I suppose you dont know till you start the "Heart worm" program on any new OES to your home wether it is "Russian Roulette" happening when you first start the preventative measures for heart worm. Sooooo I stay safe and use a product that does not contain "invermectin" now rather then testing if they can take that drug or not.  Grete I would of thought Norway with the cold & type of climate would be free of "Heartworm" is that correct?, I cant see in your climate "Mozzies" which are to blame for spreading heart worm even living there and biting either uprights or pooches.  |
| Other drugs are also said to cause neurological toxicity in dogs with the MDR1 gene mutation... it's not limited to only the higher doses of Ivermectin. Something as simple as Imodium, an anti-diarrhea drug, is to be avoided entirely. So it's important to read the list of drugs said to cause problems and their recommendations if testing isn't an option and to talk it over with your vet. http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Milbemycin is also on the list... thinking this is the same thing as milbemycin oxime which is in Interceptor and Sentinel. There is a notation on the Drs. Foster and Smith patient sheet under "Precautions" about Collies and herding dogs and not exceeding the hw preventative dosage (as with Ivermectin, not using the higher mange dosages). http://www.drsfostersmith.com/Rx_Info_S ... rtworm.pdf . Heck, selamectin is also on the list and that's in Revolution. Quote: Selamectin, milbemycin, and moxidectin (antaparasitic agents). Similar to ivermectin, these drugs are safe in dogs with the mutation if used for heartworm prevention at the manufacturer's recommended dose. Higher doses (generally 10-20 times higher than the heartworm prevention dose) have been documented to cause neurological toxicity in dogs with the MDR1 mutation. http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Anyway, according to what they're saying on their website, the heartworm preventative dosages of these drugs are safe. As always though, verify the info and talk with your vet. Is Washington State University the only place that studies and tests for the MDR1 gene? |
| Imodium has never worked very well on my dogs. I could give it for 2-3 days before I saw any change at all. I ran across a probiotic from Purina while talking to a rep at a dog show & bought some to try on my guys the next time I saw soft stool. Worked like a charm & saw results in less than 24 hours. Now I keep it on hand for anytime I start to see soft stool. I have always used Interceptor for Heartworm prevention. |
Quote: I have always used Interceptor for Heartworm prevention. Oops... I wasn't saying Interceptor was a bad or improper choice in untested dogs.  Let me try again... Like ivermectin, milbemycin and selamectin are also on that problem drug list. So I don't know that we can prevent hw and totally avoid using a drug simply because it's on the list. But it doesn't appear to be an issue anyway because the low heartworm preventative doses in all three are said to be safe. Just don't use the hw+ and mange dosages without testing. And, if a dog hasn't been tested, you'd likely want to be aware that there are more drugs on the list that are said to also cause neurological toxicity. Below is what a report from Washington State University looks like. We test every dog that comes in even though the incidence of the mutation doesn't appear to be very high in OESs. (Old English Sheepdog - 5 % and Border Collie -< 5% - http://www.vetmed.wsu.edu/depts-VCPL/breeds.aspx). Quote: MDR1 GENOTYPING RESULTS 9/17/2010 8:52:08 AM MDR1 - 18655 Submission Type: Brush Dog Name: Mequss'uk Dog Breed: Old English Sheepdog Test Result: Normal/Normal Explanation of test results Normal/Normal These dogs do not carry the mutation, and will not pass on the mutation to their offspring.These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs. Mutant/Mutant These dogs carry the mutation and can not pass on a normal gene to their offspring.These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram). Mutant/Normal These dogs carry the mutation and may pass on the mutant gene to their offspring.These dogs may experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram). A current list of problem drugs for dogs with the MDR1 mutation may be found at this web address: http://www.vetmed.wsu.edu/VCPL Problem Drugs- http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx |
| Jaci: I didn't think you meant that. I had just started the post off with Imodium & wanted to get it back to the heartworm preventative theme. I was just stating a fact of that was what my vet had always suggested for Heartworm protection for my dogs. No harm done |
Thanks, Marilyn  |
got sheep wrote: Grete - you'll have to let us know if you can test for it over there. I hope you can! Yes, we can! My vet send the blood sample to Germany........................so it is about three times more expensive than in US. lisaoes wrote: Grete I would of thought Norway with the cold & type of climate would be free of "Heartworm" is that correct?, I cant see in your climate "Mozzies" which are to blame for spreading heart worm even living there and biting either uprights or pooches.  You're absolutly right; We are lucky, we have no heartworm in Norway.I had trouble with mite - "walking dandruff" - once, on two oeses and on my cat -it is more than ten years ago. Usely it is easy to get rid of it, however we struggled for almost two years. First, it took several vets about nine months to understand that the mite were there. And then we were affected again and again from dogs who's owners didn't treat them. I told everyone my dogs had been playing with to treat their dogs too. It would have been easier if I had dared to use Ivomec. The vet thought so. At last we stopped playing with some of the dogs here and it stopped comming back. |
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