i hope this is true
read the news articles... and WOW..why arent people funding this? |
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| That is interesting. Have you Googled it to find out more?
I'll have to Google it some, too. |
| well wiki had some news on it:
http://en.wikipedia.org/wiki/Dichloroacetic_acid an online medical journel posted about it at start of year: http://scienceroll.com/2007/01/31/curin ... ate-story/ and an online forum has started up (albeit overlooked as this thing is wide spread news due to lack of proper media coverage) in order to urge for clinical trials in the US, UK and Canada: http://www.dichloroacetate.org/ its just due to its nature that it cant be patented ( ie chemical companies cant charge a bomb for it) that its not being given proper funding for studies.. which is disgusting .. |
| To do a proper study on a drug or treatment takes years and multi-millions of dollars. It is done in 4Phases.
Phase 1 These are the earliest trials in the life of a new drug or treatment. They are usually small trials, recruiting anything up to about 30 patients, although often a lot less. The trial may be open to people with any type of cancer. When laboratory testing shows a new treatment might help treat cancer, phase 1 trials are done to find out The safe dose range The side effects How the body copes with the drug If the treatment shrinks cancer Patients are recruited very slowly onto phase 1 trials. So although they don't recruit many patients, they can take a long time to complete. The first few patients to take part (called a 'cohort' or group) will be given a very small dose of the drug. If all goes well, the next group will get a slightly higher dose. The dose will gradually be increased with each group. The researchers will monitor the effect, until they find the best dose to give. This is called a 'dose escallation study'. These trials seem to be done with patients who have exhausted their other options. Phase 2 Not all treatments tested in a phase 1 trial make it to a phase 2 trial. These trials may be done on people who all have same type of cancer, or with several different types of cancer. Phase 2 trials are done to find out If the new treatment works well enough to test in a larger phase 3 trial Which types of cancer the treatment works for More about side effects and how to manage them More about the best dose to use Although these treatments have been tested at phase 1, you may still have side effects that the doctors don't know about. Drugs can affect people in different ways. Phase 2 trials are often larger than phase 1. There may be up to 50 or so people taking part. If the results of phase 2 trials show that a new treatment may be as good as existing treatment, or better, it then moves to phase 3. Phase 3 These trials compare new treatments with the best currently available treatment (the standard treatment). They may compare A completely new treatment with the standard treatment Different doses or ways of giving a standard treatment A new radiotherapy schedule with the standard one Phase 3 trials are usually much larger than phase 1 or 2. This is because differences in success rates may be small. So, you would need many patients in the trial to show the difference. Sometimes phase 3 trials involve thousands of patients in many different hospitals or clinics and even different countries. I've been involved in numerous Phase 3 trials. An unbelievable amount of paperwork and testing - and woe to the researcher who messes it up. Phase 4 Phase 4 trials are done after a drug has been shown to work and has been granted a license. So they are looking at drugs that are already available for doctors to prescribe, rather than new drugs that are still being developed. The main reasons pharmaceutical companies run phase 4 trials are to find out More about the side effects and safety of the drug What the long term risks and benefits are How well the drug works when it’s used more widely than in clinical trials Scheduling options, such as in chemotherapy regimens If a company can't potentially make money on their investment, they won't go there. There is a reason that you see so many variations of a drug - the possibility of a return is much greater. We need a billionaire to fund this research. |
| Ummmm.... did you READ about the bad reactions that everyone had, including the early halting of a trial where EVERYONE developed NERVE TOXICITY?
Quote: A separate trial of DCA in children with MELAS (a syndrome of inadequate mitochondrial function, leading to lactic acidosis) was halted early as 15 out of 15 of the children receiving DCA experienced significant nerve toxicity without any evidence of benefit from the medication.
[...] Adverse effects: Reports in the lay press after the 2007 University of Alberta announcement claim that dichloroacetate "has actually been used safely in humans for decades", but the limited scholarly literature suggests side effects of pain, numbness and gait disturbances in some patients. A clinical trial where DCA was given to patients of MELAS (a form of genetically inherited lactic acidosis) at 25 mg/kg/day was ended prematurely due to excessive peripheral nerve toxicity [see above... EVERY participant had horrendous side effects. -ed.]. Dichloroacetate can also have anxiolytic or sedative effects. Animal studies suggest that the neuropathy and neurotoxicity during chronic dichloroacetate treatment may be partly due to depletion of thiamine, and thiamine supplementation in rats reduced these effects. However, more recent studies in humans suggest that peripheral neuropathy is a common side effect during chronic DCA treatment, even with coadministration of oral thiamine. An additional study reported that 50 mg/kg/day DCA treatment resulted in unsteady gait and lethargy in two patients, with symptoms occurring after one month for one patient and two months for the second. Gait disturbance and consciousness were recovered with cessation of DCA, however sensory nerve action potentials did not recover in one month. Perhaps that is "good news" as the approach my yield some interesting ideas for the pharmas who will then invent a safe drug. |
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